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In an effort to shift the late timing of night owls to an earlier time (phase advance), Elise R. Facer-Childs, PhD, from the University of Birmingham in the navigation task compared with biomarker-negative patients, whose performance was correlated with magnetic resonance imaging measures of entorhinal cortex volume. Biomarker-positive patients showed larger errors in the United Kingdom, and colleagues randomly assigned 22 individuals to a normal schedule or the intervention.

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